Peer-reviewed veterinary case report
Maropitant stops ongoing vomiting in dogs from many causes
By de la Puente-Redondo, V A et al.·Published in The Journal of small animal practice·2007·Veterinary Medicine Research & Development, United Kingdom·View original on PubMed →
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Original publication title: The anti-emetic efficacy of maropitant (Cerenia) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe.
- Species:
- dog
Plain-English summary
A group of dogs experiencing ongoing vomiting were treated with either maropitant (Cerenia) or metoclopramide to see which medication worked better. The results showed that 97% of the dogs given maropitant stopped vomiting, compared to only 71% of those treated with metoclopramide. Additionally, the dogs on maropitant had fewer vomiting episodes overall, especially in the first 24 hours after treatment. This study suggests that a single daily dose of maropitant is more effective for treating vomiting in dogs than multiple doses of metoclopramide.
People also search for: dog vomiting treatment · Cerenia for dogs · metoclopramide side effects in dogs
Abstract
OBJECTIVES: The efficacy of maropitant (Cerenia; Pfizer Inc.) as an anti-emetic for use in dogs with ongoing emesis was evaluated in a two-phase multi-centric study conducted at veterinary clinics in France, Italy, Slovakia and the UK. METHODS: In phase I, dogs with ongoing emesis were randomised in a 1:1 ratio to either maropitant (32 dogs) or metoclopramide (34 dogs). In phase II, dogs were randomised in a 2:1 ratio to maropitant (77 dogs) or metoclopramide (40 dogs). Maropitant was administered subcutaneously at 1 mg/kg/day for up to five days. Metoclopramide was administered as recommended on the product labels as licensed at 0.5 to 1 mg/kg/day subcutaneously or orally with the daily dose divided over two to three administrations per day for up to three to five days. RESULTS: In phase I, 97 per cent of dogs treated with maropitant and 71 per cent of dogs treated with metoclopramide did not vomit after treatment (P<0.01). The mean number of emetic events after maropitant treatment was significantly reduced compared with that after metoclopramide treatment (P=0.01). In phase II, the occurrence of emesis was lower for maropitant during the first 24 hours (P<0.0001) and for each day thereafter. CLINICAL SIGNIFICANCE: A single daily dose of maropitant was more effective than metoclopramide administered two or three times daily in the treatment of emesis caused by various aetiologies in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17286662/