Peer-reviewed veterinary case report
Anti-inflammatory effects of magnolia and corn extract on dog gum
By Kim, Se Eun et al.·Published in BMC veterinary research·2024·Small Animal Clinical Research Institute, South Korea·View original on PubMed →
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Original publication title: The anti-inflammatory effect of a magnoliae cortex and Zea mays L. extract mixture in a canine model of ligature-induced periodontitis.
- Species:
- dog
Plain-English summary
A group of 10 Beagle dogs with induced periodontitis (gum disease) were treated with a combination of Magnoliae cortex and Zea mays L. extracts for two months. The dogs receiving the extracts showed significant improvement in gum inflammation, reduced periodontal pocket depth, and less bleeding compared to those who did not receive the treatment. Blood tests remained normal throughout the study, and the extracts appeared to lower inflammation markers in the dogs' tissues. Overall, the combination of these natural extracts helped improve the symptoms of periodontal disease in the treated dogs.
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Abstract
BACKGROUND: Periodontitis is common in dogs. It is characterized by destruction of the supporting tissues of the teeth due to the host-immune response triggered by plaque. Magnoliae cortex and Zea mays L. extract showed anti-inflammatory and anti-microbial effects, respectively. This study aimed to evaluate improvement in periodontitis following the administration of Magnoliae cortex and Zea mays L. extract in dogs. Periodontitis was experimentally induced in 10 beagle dogs. Five dogs were administered 40 mg of Magnoliae cortex extract and 20 mg of Zea mays L. extract orally once per day for 2 months (MZ group), whereas the other group received empty gelatin capsules (control group). Periodontal clinical parameters, complete blood count, serum chemistry parameters, and tissue inflammatory cytokines and chemokine expression were assessed before and after combined oral extracts administration. RESULTS: The complete blood count and serum chemistry results of all dogs were within normal ranges. Gingival inflammation in MZ group was significantly better than that in the control group at 4 and 8 weeks post-medication (PM; p < 0.05). The periodontal pocket depth and clinical attachment loss at 8 weeks PM in the MZ group were significantly lower than the baseline values (p < 0.05). The incidence of bleeding on probing in the MZ group was significantly lower than that in the control group at 4 weeks PM (p < 0.05). Throughout the medication period, the percentages of CD4 + and CD8 + T cells were higher and lower, respectively, in the MZ group. However, these differences were only significant at 8 weeks PM. The expression of the inflammatory cytokines IL-1β, IL-6, IL-17, and TNF-α and the chemokine IL-8 in the inflamed tissues was lower in the MZ group, and the two groups showed a significant difference in TNF-α expression. CONCLUSIONS: Combined administration of Magnoliae cortex and Zea mays L. extract improved the clinical symptoms of periodontal disease in dogs. This beneficial effect may be partly due to the inhibitory effects of these extracts on the inflammatory response.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39342169/