Peer-reviewed veterinary case report
Pardaxin treatment reduces perianal gland tumors in dogs
By Pan, Chieh-Yu et al.·Published in Oncotarget·2015·Department and Graduate Institute of Aquaculture·View original on PubMed →
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Original publication title: The antimicrobial peptide pardaxin exerts potent anti-tumor activity against canine perianal gland adenoma.
- Species:
- dog
Plain-English summary
A group of dogs with perianal gland adenomas (a type of tumor near the anus) received local injections of a substance called pardaxin, which is known for its antimicrobial properties. After treatment, the tumors showed significant shrinkage within 28 to 38 days, and there were no major side effects observed in the dogs' blood tests. This suggests that pardaxin could be a promising option for treating this type of tumor in dogs. Overall, the treatment was effective and well-tolerated, offering hope for better management of perianal gland adenomas.
People also search for: dog perianal gland tumor treatment · pardaxin for dog tumors · canine adenoma treatment options
Abstract
Pardaxin is an antimicrobial peptide of 33 amino acids, originally isolated from marine fish. We previously demonstrated that pardaxin has anti-tumor activity against murine fibrosarcoma, both in vitro and in vivo. In this study, we examined the anti-tumor activity, toxicity profile, and maximally-tolerated dose of pardaxin treatment in dogs with different types of refractory tumor. Local injection of pardaxin resulted in a significant reduction of perianal gland adenoma growth between 28 and 38 days post-treatment. Surgical resection of canine histiocytomas revealed large areas of ulceration, suggesting that pardaxin acts like a lytic peptide. Pardaxin treatment was not associated with significant variations in blood biochemical parameters or secretion of immune-related proteins. Our findings indicate that pardaxin has strong therapeutic potential for treating perianal gland adenomas in dogs. These data justify the veterinary application of pardaxin, and also provide invaluable information for veterinary medicine and future human clinical trials.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25544775/