Peer-reviewed veterinary case report
The antimicrobial peptide pardaxin exerts potent anti-tumor activity against canine perianal gland adenoma.
- Journal:
- Oncotarget
- Year:
- 2015
- Authors:
- Pan, Chieh-Yu et al.
- Affiliation:
- Department and Graduate Institute of Aquaculture
- Species:
- dog
Plain-English summary
Researchers studied a substance called pardaxin, which is a small protein originally found in fish, to see if it could help treat a specific type of tumor in dogs known as perianal gland adenoma. They found that when pardaxin was injected directly into the tumors, it significantly slowed their growth over a period of 28 to 38 days. The treatment did not seem to cause any major side effects or changes in the dogs' blood tests. Overall, the results suggest that pardaxin could be a promising option for treating these tumors in dogs.
Abstract
Pardaxin is an antimicrobial peptide of 33 amino acids, originally isolated from marine fish. We previously demonstrated that pardaxin has anti-tumor activity against murine fibrosarcoma, both in vitro and in vivo. In this study, we examined the anti-tumor activity, toxicity profile, and maximally-tolerated dose of pardaxin treatment in dogs with different types of refractory tumor. Local injection of pardaxin resulted in a significant reduction of perianal gland adenoma growth between 28 and 38 days post-treatment. Surgical resection of canine histiocytomas revealed large areas of ulceration, suggesting that pardaxin acts like a lytic peptide. Pardaxin treatment was not associated with significant variations in blood biochemical parameters or secretion of immune-related proteins. Our findings indicate that pardaxin has strong therapeutic potential for treating perianal gland adenomas in dogs. These data justify the veterinary application of pardaxin, and also provide invaluable information for veterinary medicine and future human clinical trials.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25544775/