Peer-reviewed veterinary case report
Does oclacitinib reduce antibiotic use in dogs with allergic
By Rynhoud, Hester et al.·Published in Frontiers in veterinary science·2021·School of Veterinary Science, Australia·View original on PubMed →
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Original publication title: The Association Between the Use of Oclacitinib and Antibacterial Therapy in Dogs With Allergic Dermatitis: A Retrospective Case-Control Study.
- Species:
- dog
Plain-English summary
A group of dogs with allergic dermatitis, including atopic dermatitis, were treated with oclacitinib, a medication that helps relieve itching. The study found that these dogs needed fewer antibiotics compared to those treated with other anti-itch medications. In fact, dogs on oclacitinib showed significant improvements in their skin condition and had lower chances of needing both systemic and topical antibiotics. This suggests that oclacitinib not only helps manage itching but may also reduce the risk of secondary infections in dogs with allergic dermatitis.
People also search for: dog allergic dermatitis treatment · oclacitinib for dog itching · dog skin infection antibiotics
Abstract
Canine allergic dermatitis, including atopic dermatitis, often requires antibacterial therapy for concurrent infections. Oclacitinib is indicated for treatment of pruritus associated with allergic dermatitis and the clinical manifestations of atopic dermatitis in dogs aged ≥12 months.We aimed to determine if there was a quantitative difference in antibacterial use by dogs with allergic dermatitis receiving oclacitinib vs. other anti-pruritic therapies and before vs. after oclacitinib.In this retrospective case-control study, cases (= 58) included dogs suffering from allergic dermatitis aged ≥12 months receiving oclacitinib and controls (= 205) were counterpart dogs treated with other anti-pruritic therapies.Clinical histories of dogs with allergic dermatitis were collected from a small animal university hospital. Multivariable logistic regression models were developed adjusting for underlying skin or ear conditions to determine whether cases were prescribed fewer antibacterials than controls.The odds of systemic antibacterial usage were lower in cases vs. controls [odds ratio (OR): 0.29 (95% confidence interval 0.12-0.71);= 0.007]. The odds of amoxycillin clavulanic acid usage (12.5-25 mg/kg orally every 12 h) was lower in cases vs. controls [OR: 0.08 (0.01-0.71);= 0.024]. Topical antibacterial drug use was reduced overall; however, only the odds of neomycin use was lower in cases vs. controls [OR: 0.3 (0.1-0.89);= 0.029]. Cases had higher odds of experiencing improvements in allergic dermatitis categories vs. controls [OR: 7.89 (3.26-19.13);< 0.001].Our results suggest that use of oclacitinib to treat allergic dermatitis in dogs is associated with less antibacterial use than other anti-pruritic therapies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33681331/