Peer-reviewed veterinary case report
Bacteriuria's effect on survival and kidney disease in cats
By Hindar, Camilla et al.·Published in Journal of veterinary internal medicine·2020·Department of Clinical Science and Services, United Kingdom·View original on PubMed →
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Original publication title: The association of bacteriuria with survival and disease progression in cats with azotemic chronic kidney disease.
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) and urinary tract infections (UTIs) were studied to see if the infections affected their survival or the progression of their kidney disease. The research found that whether the cats had no infections, one infection, or multiple infections, their survival times and the progression of CKD were not significantly different. Importantly, when the cats received antibiotics for their infections, it did not change the outcome of their kidney disease. This suggests that while UTIs are common in cats with CKD, treating them does not impact their overall health related to kidney disease.
People also search for: cat chronic kidney disease treatment · cat urinary tract infection antibiotics · cat kidney disease survival rate
Abstract
BACKGROUND: Cats with chronic kidney disease (CKD) have an increased prevalence of positive urine cultures (PUC). Limited information is available regarding the prognosis of cats with CKD and concurrent PUC. OBJECTIVE: To determine the association of PUC with survival time and disease progression in cats with CKD. ANIMALS: Medical records of 509 cats diagnosed with azotemic CKD between 1997 and 2018. METHODS: Cats were classified as having "no-PUC" or "PUC." The PUC cats were further classified as having 1 or multiple PUC, and also were classified based on the presence or absence of clinical signs of urinary tract infection (UTI). Progression of CKD was defined as a plasma creatinine concentration increase of ≥25% within 365 days of CKD diagnosis; PUC also must have occurred within this time frame. Survival time and frequency of CKD progression were compared between groups. RESULTS: No significant difference in survival time was found between cats with no-PUC and cats with any number of PUC (P = .91), or between cats with no-PUC, 1 PUC or multiple PUC (P = .37). Also, no significant difference was found in the frequency of CKD progression between PUC and no-PUC cats (P = .5), or among no-PUC, 1 PUC and multiple PUC cats (P = .22). When assessing cats with clinical signs of lower UTI, no significant difference was found in the frequency of CKD progression between cats with true UTI, subclinical bacteriuria or no-PUC (P = .8). CONCLUSIONS AND CLINICAL IMPORTANCE: When treated with antibiotics, PUC in cats with CKD do not affect disease progression or survival time.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33016500/