Peer-reviewed veterinary case report
Topical flurbiprofen and risk of glaucoma after dog cataract surgery
By Kang, Seonmi et al.·Published in Veterinary ophthalmology·2021·Department of Veterinary Clinical Sciences, South Korea·View original on PubMed →
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Original publication title: The association of topical flurbiprofen with the incidence of postoperative glaucoma after phacoemulsification in dogs.
- Species:
- dog
Plain-English summary
A group of 65 dogs, averaging 8 years old, underwent eye surgery to remove cataracts. After surgery, some dogs were given a combination of flurbiprofen (a pain reliever) and corticosteroids, while others received only corticosteroids. It was found that dogs receiving flurbiprofen had a much higher chance of developing glaucoma afterward, with 39.5% of those treated with flurbiprofen experiencing glaucoma compared to just 4.4% of those who did not. To reduce the risk of glaucoma after cataract surgery, it may be best to avoid using flurbiprofen immediately after the procedure.
People also search for: dog eye surgery complications · glaucoma treatment for dogs · cataract surgery recovery in dogs
Abstract
OBJECTIVE: To investigate the relationship between topical administration of flurbiprofen plus corticosteroids versus corticosteroids alone following phacoemulsification and the development of postoperative glaucoma in dogs. ANIMAL STUDIED: Thirty-eight/eighty-three (45.8%) eyes were prescribed topical flurbiprofen plus corticosteroids immediately postop while 45/83 (54.2%) eyes received topical corticosteroids alone. PROCEDURES: Logistic regression models were performed to analyze the relationship between topical flurbiprofen and development of glaucoma and to predict potential risk factors for postoperative glaucoma occurrence. RESULTS: Eighty-three eyes (65 dogs) were included. The mean age at surgery was 8.2 years, with even gender distribution. Increasing age at the time of surgery significantly increased the probability of postoperative glaucoma occurrence (odds ratio [OR] = 1.344, 95% confidence interval [CI] 1.093-1.652; p = 0.005). Glaucoma occurred in 17/83 (20.5%) eyes; of these, 15/38 (39.5%) and 2/45 (4.4%) eyes were prescribed topical flurbiprofen plus corticosteroids and topical corticosteroids alone, respectively. Immediate postoperative use of topical flurbiprofen was significantly associated with an increased probability of postoperative glaucoma occurrence (OR = 19.183 [95% CI 3.367-109.286], p = 0.001). CONCLUSIONS: Immediate postoperative use of topical flurbiprofen was a potential predisposing risk factor for the development of glaucoma following phacoemulsification. Restriction of postoperative use of topical flurbiprofen might decrease the possibility of postoperative glaucoma development in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34402562/