Peer-reviewed veterinary case report
Erythritol stops bacteria that cause dog gum disease
By Tochio, T et al.·Published in Polish journal of veterinary sciences·2022·B Food Science Co., Japan·View original on PubMed →
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Original publication title: The bacteriostatic effect of erythritol on canine periodontal disease-related bacteria.
- Species:
- dog
Plain-English summary
A study found that erythritol, a sugar alcohol often used in human dental care, can help fight bacteria related to periodontal disease in dogs. In the lab, erythritol significantly reduced the growth of a harmful bacteria called Porphyromonas gulae, which is linked to gum disease in dogs. In a 4-week trial with dogs that had mild periodontal disease, a gel containing 5% erythritol was applied, leading to a decrease in harmful bacteria around their gums. This suggests that erythritol could be a beneficial addition to dental care for dogs, helping to improve their oral health.
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Abstract
Erythritol helps both prevent and improve periodontal disease and is therefore widely used for dental care in humans. However, only a few studies have investigated the effects of erythritol on periodontal disease in animals. We hypothesized that erythritol could be used to prevent and improve periodontal disease also in canines and investigated the effects of erythritol on canine periodontal disease-related pathogenic bacteria using both in vitro and in vivo methods. The effect of erythritol on the proliferation of Porphyromonas gulae, which is reportedly associated with canine periodontal disease, was investigated in vitro. In addition, a 4-week intervention trial using an external gel preparation containing 5% erythritol was performed in canines with mild periodontal disease; changes in the microbiota around periodontal lesions were investigated using next-generation sequencing and bioinformatics analysis. The growth of P. gulae was significantly suppressed by erythritol in vitro. In the intervention study, the Shannon index, an indicator of the species distribution α-diversity, and the occupancy of several canine periodontal disease - related bacteria ( P. gulae, P. cangingivalis) were significantly decreased in periodontal lesions. Based on the results of in vitro and in vivo studies, we conclude that, as in humans, erythritol has bacteriostatic effects against periodontal disease - related bacteria in canines.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35575772/