Peer-reviewed veterinary case report
The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 × Tg-AD) mouse model strain.
- Journal:
- Experimental neurology
- Year:
- 2023
- Authors:
- Tian, Sheng et al.
- Affiliation:
- Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine · China
Abstract
As a classic animal model of Alzheimer's disease (AD), the 3 × Tg-AD mouse not only recapitulates most of anatomical hallmarks observed in AD pathology but also displays cognitive alterations in memory and learning tasks. The 3 × Tg-AD can better show the two characteristics of AD, amyloid β (Aβ) and neurofibrillary tangles (NFT). Therefore, 3 × Tg-AD strain is widely used in AD pathogenesis research and new drug development of AD. In this paper, the construction methods, pathological changes, and treatment characteristics of 3 × Tg-AD mouse models commonly used in AD research are summarized and commented, hoping to provide reference for researchers to choose and establish experimental patterns.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37597764/