Peer-reviewed veterinary case report
How the new H3N2 canine flu virus infects beagles and spreads
By Ge, Fei-Fei et al.·Published in Virology journal·2024·Shanghai Animal Disease Control Center, China·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: The biological characteristics and infection dynamics of a novel H3N2 canine influenza virus genotype in beagles.
- Species:
- dog
Plain-English summary
A group of beagles was studied to understand a new strain of the canine influenza virus (CIV) that emerged in 2019. The dogs infected with a lower dose of the virus showed the most severe symptoms, including respiratory issues and lung damage, while those given higher doses had milder reactions. This research helps to identify how the virus spreads and affects dogs, which is important for developing better prevention strategies.
People also search for: dog coughing and sneezing · canine influenza symptoms · beagle flu treatment · how to prevent dog flu
Abstract
BACKGROUND: The canine influenza virus (CIV) outbreak has garnered considerable attention as it poses a significant threat to dog health. During the H3N2 CIV evolution in beagles, the virus formed a new clade after 2019 and gradually became more adaptable to other mammals. Therefore, successfully elucidating the biological characteristics and constructing a canine influenza infection model is required for CIV characterization. METHODS: We performed genetic analyses to examine the biological characteristics and infection dynamics of CIV. RESULTS: The genotype of our H3N2 CIV strain (from 2019 in Shanghai) belonged to the 5.1 clade, which is now prevalent in China. Using MDCK cells, we investigated viral cytopathic effects. Virus size and morphology were observed using transmission electron microscopy. Beagles were also infected with 10, 10, and 1050% egg-infectious doses (EID). When compared with the other groups, the 10EIDgroup showed the most obvious clinical symptoms, the highest virus titers, and typical lung pathological changes. Our results suggested that the other two treatments caused mild clinical manifestations and pathological changes. Subsequently, CIV distribution in the 10EIDgroup was detected by hematoxylin and eosin (H&E) and immunofluorescence (IF) staining, which indicated that CIV primarily infected the lungs. CONCLUSIONS: The framework established in this study will guide further CIV prevention strategies.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38965616/