Peer-reviewed veterinary case report
The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease.
- Journal:
- The Journal of infectious diseases
- Year:
- 2018
- Authors:
- DeWald, Lisa Evans et al.
- Affiliation:
- National Institute of Allergy and Infectious Diseases
Abstract
No therapeutics are approved for the treatment of filovirus infections. Bepridil, a calcium channel blocker developed for treating angina, was identified as a potent inhibitor of filoviruses in vitro, including Ebola and Marburg viruses, and Ebola virus in vivo. We evaluated the efficacy of bepridil in a lethal mouse model of Marburg virus disease. A dose of 12 mg/kg bepridil once or twice daily resulted in 80% or 90% survival, respectively. These data confirm bepridil's broad-spectrum anti-filovirus activity warranting further investigation of bepridil, or improved compounds with a similar mechanism, as a pan-filovirus therapeutic agent.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29982632/