Peer-reviewed veterinary case report
Canine Orthopedic Index detects arthritis improvement with carprofen
By Brown, Dorothy Cimino·Published in Veterinary Surgery·2014·Veterinary Clinical Investigations Center, School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania, United States·View original on Crossref →
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Original publication title: The Canine Orthopedic Index. Step 3: Responsiveness Testing
- Species:
- dog
Plain-English summary
A group of 80 dogs with osteoarthritis (OA) were given either a common pain medication called carprofen or a placebo to see how it affected their symptoms. Owners filled out a questionnaire about their dogs' stiffness, movement, and overall function at the start and after two weeks. The results showed that dogs taking carprofen had significant improvements in their stiffness, gait, and function compared to those on the placebo. However, there wasn't a noticeable difference in their quality of life scores. Overall, carprofen helped reduce the pain and improve mobility in dogs with OA.
People also search for: dog osteoarthritis treatment · carprofen for dog arthritis · how to help my dog with joint pain
Abstract
ObjectiveTo determine whether the Canine Orthopedic Index (COI) can detect changes in dogs with osteoarthritis (OA) treated with either non‐steroidal anti‐inflammatory drugs (NSAID) or placebo.Study DesignDouble blind randomized placebo controlled trial.AnimalsDogs (n = 80) with OA.MethodsOwners completed the COI on Day 0. Dogs were administered either carprofen or placebo on days 1 through 14. Owners completed the COI again on Day 14. The change in total instrument, stiffness, gait, function, and quality of life scores were assessed between groups.ResultsDogs administered carprofen had significant decreases in the total instrument score (P = .002) as well as 3 of the 4 factor scores compared to dogs treated with placebo (stiffness scoreP = .015; gait scoreP = .001; and function score = 0.008). The change in quality of life score was not significantly different between carprofen and placebo treated dogs (P = .124).ConclusionsThe COI delivered the decreases in total instrument, stiffness, gait, and function scores that one would expect in dogs with OA treated with an NSAID compared with placebo administration. In this cohort of dogs, the quality of life score was not sensitive to the changes associated with NSAID administration.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1532-950x.2014.12162.x