Peer-reviewed veterinary case report
Heart effects of sevoflurane vs isoflurane in healthy dogs under
By Abed, Janan M et al.·Published in Journal of the American Animal Hospital Association·2014·Department of Emergency and Critical Care, United States·View original on PubMed →
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Original publication title: The cardiovascular effects of sevoflurane and isoflurane after premedication of healthy dogs undergoing elective surgery.
- Species:
- dog
Plain-English summary
A group of healthy dogs undergoing elective surgery were given either sevoflurane or isoflurane for anesthesia to see how each affected their heart and blood pressure. Nineteen dogs were monitored during surgery, and both anesthetics showed similar effects on their cardiovascular health. The dogs were premedicated with hydromorphone and glycopyrrolate before anesthesia. Overall, both types of anesthesia were safe and effective for these dogs during their procedures.
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Abstract
Sevoflurane and isoflurane are commonly used in veterinary anesthesia. The objective of this prospective, randomized, open-label clinical study was to compare the cardiovascular effects of sevoflurane and isoflurane via direct arterial blood pressure measurements and the lithium dilution cardiac output (LDCO) on premedicated healthy dogs undergoing elective tibial plateau leveling osteotomy (TPLO). Nineteen client-owned dogs were included. All dogs were premedicated with hydromorphone (0.05 mg/kg IV and glycopyrrolate 0.01 mg/kg subcutaneously). Ten dogs were anesthetized with sevoflurane and nine dogs were anesthetized with isoflurane. Eighteen dogs were instrumented with a dorsal pedal arterial catheter, and one dog had a femoral arterial catheter. All dogs had continuous, direct systolic (SAP), diastolic (DAP), and mean arterial (MAP) blood pressure readings as well as heart rate (HR), cardiac output (CO), cardiac index (CI), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI), stroke volume variation (SVV), and pulse pressure variation (PPV) recorded q 5 min during the surgical procedure. There was no significant statistical difference in all parameters between the sevoflurane and isoflurane treatment groups. Both sevoflurane and isoflurane inhalant anesthetics appear to have similar hemodynamic effects when used as part of a multimodal anesthetic protocol in premedicated healthy dogs undergoing an elective surgical procedure.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24216497/