Peer-reviewed veterinary case report
The centrally acting non-narcotic antitussive tipepidine produces antidepressant-like effect in the forced swimming test in rats.
- Journal:
- Behavioural brain research
- Year:
- 2009
- Authors:
- Kawaura, Kazuaki et al.
- Affiliation:
- Department of Environmental and Molecular Health Sciences · Japan
- Species:
- rodent
Abstract
The antidepressant-like effect of tipepidine was studied in rats. Tipepidine at 20 and 40 mg/kg i.p. reduced immobility in the forced swimming test and tipepidine at 40 mg/kg, i.p. increased climbing in the test. The drug at 40 mg/kg, i.p. had no effect on the locomotor activity and motor coordination. These results suggest that tipepidine may be a novel drug with antidepressant-like activity.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19616036/