Peer-reviewed veterinary case report
Trends in Chronic Pancreatitis Research from 2000 to 2023
By Jiang LY et al.·2026·Department of Gastroenterology, China·View original on Europe PMC →
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Original publication title: The Changing Landscape of Chronic Pancreatitis Research Trajectories Over Two Decades: A Global Meta-Analysis Using MeSH Terms.
Plain-English summary
Recent research on chronic pancreatitis, a condition where the pancreas becomes inflamed over time, has made significant strides over the past two decades. A study reviewed thousands of publications from 2000 to 2023 to identify trends in this area. It found that while some topics, like inflammation and the quality of life for patients, are gaining attention, others are becoming less popular. Current research is focusing on how to improve patients' lives, including managing pain and exploring new treatments like pancreatic islet transplantation. Overall, the findings suggest that both basic science and clinical studies are driving advancements in understanding and treating chronic pancreatitis.
Abstract
<h4>Objectives</h4>Significant progress has been made in research on chronic pancreatitis (CP). It is essential to analyze recent trends in this field to guide future clinical investigations.<h4>Methods</h4>Publications related to CP research from 2000 to 2023 were retrieved from PubMed. An analysis was conducted on Medical Subject Headings (MeSH) terms, publication dates, and affiliations. For MeSH terms with a frequency greater than 30 times, co-occurrence analysis was performed to demonstrate the overall trend of CP research. For those that occurred more than 200 times, heat maps, 3D surface maps, and Ribbon Charts were created to illustrate the trend of changes every 2 years.<h4>Results</h4>A total of 14,260 publications with 6775 MeSH terms from 2000 to 2023 were retrieved, and six clusters were obtained from the co-occurrence analysis. From 2000 to 2023, 35 MeSH terms with decreasing trends and 7 MeSH terms with increasing trends (MH-I) were selected to create a heat map. 7 MH-I were "signal transduction," "inflammation," "quality of life," "diabetes mellitus, type 2," "exocrine pancreatic insufficiency," "islets of Langerhans transplantation," and "transplantation, autologous."<h4>Conclusion</h4>The 21<sup>st</sup> century has witnessed CP research being propelled by both basic science and clinical research. Pathogenesis research focuses on signal transduction, while clinical research mainly focuses on the CP patients' quality of life, including pain, endocrine and exocrine function of the pancreas, among which pancreatic islet autograft transplantation is currently a hot topic. Emerging research topics such as stem cells and gut microbiota offer novel approaches for CP therapy.
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Search related cases →Original publication on Europe PMC: https://europepmc.org/article/MED/41891386