Peer-reviewed veterinary case report
The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions.
- Journal:
- Cell host & microbe
- Year:
- 2019
- Authors:
- Noll, Kelsey E et al.
- Affiliation:
- Department of Microbiology and Immunology · United States
Abstract
Host genetic variation has a major impact on infectious disease susceptibility. The study of pathogen resistance genes, largely aided by mouse models, has significantly advanced our understanding of infectious disease pathogenesis. The Collaborative Cross (CC), a newly developed multi-parental mouse genetic reference population, serves as a tractable model system to study how pathogens interact with genetically diverse populations. In this review, we summarize progress utilizing the CC as a platform to develop improved models of pathogen-induced disease and to map polymorphic host response loci associated with variation in susceptibility to pathogens.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/30974083/