Peer-reviewed veterinary case report
The contribution of PmrAB to the virulence of a clinical isolate of Escherichia coli.
- Journal:
- Virulence
- Year:
- 2013
- Authors:
- Warner, Douglas M et al.
- Affiliation:
- Center for Adaptation Genetics and Drug Resistance and the Department of Molecular Biology and Microbiology · United States
Abstract
Previous data from our laboratory suggest a relationship between increased pmrAB expression and virulence in an Escherichia coli mouse infection model of pyelonephritis. Competitive infections with wild type and pmrAB mutants showed that disruption of pmrAB caused decreased persistence of E. coli within the mouse kidney. These results were confirmed with plasmid-mediated complementation of the pmrAB mutant. Additionally, increased expression of pmrAB from this complementing plasmid in a previously attenuated marA-rob-soxS triple mutant displayed increased bacterial persistence in the infection when compared with the triple mutant alone. These findings suggest a role for this two-component regulatory system in the virulence of E. coli in a murine pyelonephritis model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23921442/