Peer-reviewed veterinary case report
The corridor task: striatal lesion effects and graft-mediated recovery in a model of Huntington's disease.
- Journal:
- Behavioural brain research
- Year:
- 2007
- Authors:
- Döbrössy, Máté D & Dunnett, Stephen B
- Affiliation:
- School of Biosciences · United Kingdom
Abstract
Experimental validation of cell replacement therapy as a treatment of neurodegenerative diseases requires the demonstration of graft-mediated behavioural recovery. The Corridor task proved to be simple and efficient to conduct with a robust ipsilateral retrieval bias in our rodent Huntington's disease model. The Corridor task is a viable behavioural option, particularly to non-specialised laboratories, for the evaluation of lateralised striatal damage and the probing of alternative therapeutic strategies, including transplantation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17383020/