Peer-reviewed veterinary case report
The curative and antioxidative efficiency of ivermectin and ivermectin + vitamin E-selenium treatment on canine Sarcoptes scabiei infestation.
- Journal:
- Veterinary research communications
- Year:
- 2011
- Authors:
- Behera, Suvendu Kumar et al.
- Affiliation:
- Indian Veterinary Research Institute · India
- Species:
- dog
Plain-English summary
This study looked at how well ivermectin, a common treatment for scabies, works on dogs infested with Sarcoptes scabiei mites, and whether adding vitamin E and selenium helps. They treated 22 dogs with scabies and compared them to 9 healthy dogs, all between 6 months and 2 years old. The dogs with scabies were split into two groups: one received just ivermectin, while the other got ivermectin along with vitamin E and selenium. After treatment, the dogs that received the additional vitamins showed better recovery compared to those that only got ivermectin. Overall, the combination of ivermectin with vitamin E and selenium helped the dogs recover more quickly from their scabies infestation.
Abstract
The objective of the present study was to investigate the curative and antioxidative efficacy of ivermectin and ivermectin + vitamin E-selenium, and the influence of these agents on oxidative stress parameters in canines infested by Sarcoptes scabiei. Twenty two sarcoptic mites infested dogs and nine healthy dogs of 6 months to 2 years of age were divided into three groups. Group I comprised of healthy dogs (n=9) whereas animals in group II (n=11) and III (n=11) were positive for scabies. Group II animals were treated with only 1% ivermectin @ 0.2 mg/kg SC whereas group III were additionally treated with Vitamin E and selenium (tocopherol 50 mg + Se 1.5 mg/ml) @ 0.5 ml/20 kg IM at weekly intervals for three times. Blood samples were collected on day 0 and 28 post therapy. The values for hemato-biochemical parameters and activities of antioxidant enzymes were significantly decreased (P<0.05) whereas level of lipid peroxidation was significantly increased in all the infested dogs in comparison to the healthy dogs on day 0 which approached normalcy by day 28 post therapy. The dogs of group III showed better clinical recovery in comparison to group II at the end of therapy. Thus, administration of vitamin E and selenium in addition to standard therapy can alleviate these alterations hastening the clinical recovery of diseased dogs and can be recommended as an adjunct therapy with miticides for canine sarcoptic mange.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21336571/