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Peer-reviewed veterinary case report

The curious case of a cryptic Cryptosporidium and a missing dendritic cell subset.

Journal:
Trends in parasitology
Year:
2022
Authors:
Lee, Donguk et al.
Affiliation:
Department of Pathology · United States
Species:
rodent

Abstract

Animal models for studying immune responses to Cryptosporidium, a parasite that causes gastrointestinal disease, have been a challenge due to the parasite's poor infectivity in mice. Russler-Germain et al. discovered a 'commensal' strain of Cryptosporidium, capable of stable infection and vertical transmission, that elicits a T helper type 1 (Th1) response to promote intestinal homeostasis.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/34953724/