Peer-reviewed veterinary case report
The cytologic features of biliary diseases: A retrospective study.
- Journal:
- Veterinary clinical pathology
- Year:
- 2020
- Authors:
- Masserdotti, Carlo
- Affiliation:
- IDEXX Laboratories Italia S.r.l. · Italy
- Species:
- cat
Plain-English summary
This study looked at liver samples from dogs and cats that had specific liver diseases known as cholangiopathies, which affect the bile ducts. Researchers reviewed 196 samples, finding different types of changes in liver cells and inflammatory cells that can help identify these diseases. They noted that while a detailed tissue examination is often needed for a clear diagnosis, the cytology (study of cells) can still provide useful information about several types of cholangiopathies in both species. Overall, the findings suggest that examining these liver cells can help veterinarians recognize liver problems related to bile flow issues and other conditions.
Abstract
BACKGROUND: Histologic examination, together with clinical data and instrument support, contributes to the recognition of biliary diseases. Although quantitative and qualitative changes in hepatic and biliary cells can occur, descriptions of cytologic samples from the liver affected by cholangiopathies are rare. OBJECTIVES: This study aimed to describe the quantitative and qualitative changes in cholangiocytes, hepatocytes, and inflammatory cells in cytologic samples from dogs and cats affected by histologically confirmed cholangiopathies. METHODS: Cytologic samples from the liver with histologically confirmed cholangiopathies were reviewed and compared to describe the changes seen on cytology. The samples were obtained from the Archive of Clinica Veterinaria Sant'Antonio and the Laboratorio Veterinario Bresciano. Statistical analysis was not performed. RESULTS: A total of 196 cytologic samples retrieved from the database fit the selection criteria, 88 from dogs, and 108 from cats. A total of eight categories of cholangiopathies have been identified and described, while histology is often required to achieve a definitive diagnosis, six categories of cholangiopathy in dogs and seven in cats provide cytologic information. CONCLUSIONS: Cytologic examination, together with clinical and ultrasonographic data, can be useful for identifying hepatic abnormalities in acute and chronic cholestasis, chronic cholangitis, feline lymphoplasmacytic cholangitis, and cholangiocellular neoplasms.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32893397/