Peer-reviewed veterinary case report
Allergy antibodies to house dust mites in Malaysian dogs with itchy
By Chan, Wei Yee et al.·Published in Veterinary immunology and immunopathology·2019·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: The detection of house dust mite Dermatophagoides farinae, Der f 2 and Zen-1 allergen-specific immunoglobulin E antibodies in dogs with atopic Dermatitis in Malaysia.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a chronic itchy skin condition) in Malaysia were tested for allergies to house dust mites and specific proteins. The study found that about 25% of the dogs had an allergy to the crude dust mite extract, nearly half were allergic to a specific dust mite protein called Der f 2, and about 30% reacted to another protein called Zen-1. These findings suggest that these allergens are significant contributors to skin problems in affected dogs. Testing for these allergies can help veterinarians recommend targeted treatments, such as immunotherapy, to relieve symptoms.
People also search for: dog itchy skin treatment · house dust mite allergy in dogs · atopic dermatitis in dogs treatment
Abstract
Canine atopic dermatitis (AD) is a chronic, inflammatory and pruritic allergic skin disease in dogs. House dust mites such as Dermatophagoides farinae are one of the known causative agents for the induction of canine AD worldwide. D. farinae protein Der f 2 is known as an important allergen involved in canine AD and recently, Zen-1 has also been identified as an allergenic protein. There is limited information on the prevalence and role of allergen sensitization to crude D. farinae extract (CDF), Der f 2 and Zen-1 among dogs diagnosed with AD in Malaysia. The aim of this study was to determine the proportion of CDF-, Der f 2- and Zen-1-specific reactive sera among dogs diagnosed with AD in Malaysia using an enzyme-linked immunosorbent assay (ELISA). Serum samples were collected from dogs diagnosed with AD from several veterinary clinics in Malaysia. The canine case records were retrieved and information on signalment, dermatological and non-dermatological histories, clinical presentation, food allergies, and exclusion of ectoparasitic, microbial and fungal skin infections were obtained through a survey form. All serum samples were evaluated to quantify the CDF-, Der f 2- and Zen-1-specific immunoglobulin E (IgE) levels. A total of 24.6%, 48.4% and 29.8% of dogs diagnosed with AD were positive for CDF-, Der f 2- and Zen-1-specific IgE, respectively. These results suggest that CDF-, Der f 2- and Zen-1 are important allergens that can contribute to AD in dogs in Malaysia, and serological testing can be performed to provide additional treatment options involving specific immunotherapies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31213251/