Peer-reviewed veterinary case report
Changes in LDH isoenzyme 3 and D-dimer after dog lung blood clots
By Ben, Su-qin et al.·Published in Thrombosis research·2007·Department of Respiratory Medicine, China·View original on PubMed →
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Original publication title: The dynamic changes of LDH isoenzyme 3 and D-dimer following pulmonary thromboembolism in canine.
- Species:
- dog
Plain-English summary
A group of dogs experienced breathing problems due to a condition called pulmonary thromboembolism (PTE), where blood clots block blood flow in the lungs. Researchers monitored changes in certain blood markers, specifically D-dimer and LDH-3, after inducing PTE in the dogs. They found that D-dimer levels peaked two hours after the clots were introduced, while LDH-3 levels peaked at 24 hours. These findings suggest that measuring D-dimer and LDH-3 could help veterinarians diagnose PTE more effectively.
People also search for: dog breathing problems · pulmonary thromboembolism in dogs · D-dimer test for dogs
Abstract
INTRODUCTION: To investigate the time course of changes of lactic acid dehydrogenase (LDH), LDH isoenzymes and D-dimer levels following acute pulmonary thromboembolism (PTE). MATERIALS AND METHODS: Eighteen dogs were randomly divided into three groups. Acute PTE was induced by injection of preformed blood clots into pulmonary artery through femoral vein. Thrombin and human fibrinogen were delivered into blood clots in embolism group I. Only thrombin was delivered into blood clots in embolism group II. The control group received normal saline and human fibrinogen in the same manner. Series of blood samples were collected pre-embolism and post-embolism. LDH isoenzymes proportion and D-dimer levels were measured. RESULTS: At 30 min, 1 h, 2 h, 4 h, 24 h post-embolism, the plasma D-dimer levels from embolism group I were significantly higher than pre-embolism and those from control group at the same intervals (p<0.05). The peak appeared at 2 h post-embolism (2.336+/-0.326 vs. 0.016+/-0.013, p<0.05). At 4 h, 24 h and 48 h post-embolism, total serum LDH activity and LDH-3 proportion from two embolism groups were significantly higher than pre-embolism (p<0.05). The peak of LDH-3 proportion in two embolism groups both appeared at 24 h post-embolism (0.225+/-0.021 vs. 0.108+/-0.030, 0.214+/-0.011 vs. 0.096+/-0.031, respectively. p<0.05). CONCLUSIONS: The LDH-3 and D-dimer levels were changed dynamically with a relative specificity manner during the course of acute massive PTE. Combination the D-dimer assay with LDH-3 may have a potential value in diagnosing acute massive PTE.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17258798/