Peer-reviewed veterinary case report
How trilostane affects immune cells in dogs with pituitary
By Oda, Hitomi et al.·Published in The Journal of veterinary medical science·2016·School of Veterinary Nursing and Technology, Japan·View original on PubMed →
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Original publication title: The effect of 1 year of trilostane treatment on peripheral lymphocyte subsets in dogs with pituitary-dependent hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of eight dogs with pituitary-dependent hyperadrenocorticism (a condition causing high cortisol levels) were treated with trilostane for a year to see how it affected their immune cells. While the dogs showed lower cortisol levels after treatment, the specific types of white blood cells (lymphocytes) did not change significantly. However, there was a notable decrease in overall white blood cell counts during the treatment. This suggests that while trilostane helps manage cortisol levels, it doesn't greatly impact the immune system in these dogs.
People also search for: dog Cushing's disease treatment · trilostane for dogs · high cortisol levels in dogs
Abstract
This study investigated the changes in lymphocyte subsets during the trilostane medication of Pituitary-dependent hyperadrenocorticism (PDH) dogs. The cortisol level and lymphocyte subsets of eight dogs with PDH were monitored 0, 1, 3, 6, 9 and 12 months after the initiation of trilostane treatment. White blood cells (WBC), lymphocytes, CD3(+) (T lymphocyte), CD4(+) (helper T lymphocyte), CD8(+) (cytotoxic T lymphocyte) and CD21(+) (B lymphocyte) cells were measured. Although the post-ACTH stimulation test cortisol level was significantly lower during trilostane treatment, changes in the CD3(+), CD4(+), CD8(+) and CD21(+) counts were not observed. Meanwhile, significant decrease was observed in WBC counts during trilostane treatment. These indicate that long-term trilostane treatment has little effect on the lymphocyte subsets in PDH dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26782012/