Peer-reviewed veterinary case report
How benign prostate growth affects dog sperm and prostate fluid
By Domosławska, A et al.·Published in Polish journal of veterinary sciences·2023·Department of Animal Reproduction with Clinic·View original on PubMed →
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Original publication title: The effect of benign prostatic hyperplasia on total antioxidant capacity and protein peroxidation in canine prostatic fluid and spermatozoa.
- Species:
- dog
Plain-English summary
A group of 40 intact dogs with benign prostatic hyperplasia (BPH) showed signs of reduced antioxidant levels and increased protein damage in their prostatic fluid and sperm. This condition can affect the overall health of the prostate and potentially impact fertility. The study found that dogs with BPH had lower total antioxidant capacity and higher levels of certain harmful proteins compared to healthy dogs. While the findings suggest that oxidative stress plays a role in BPH, more research is needed to explore how antioxidants might help in treating this condition.
People also search for: dog prostatic hyperplasia symptoms · antioxidants for dog prostate health · dog fertility issues BPH treatment
Abstract
The aim of this study was to evaluate the antioxidative/oxidative status of spermatozoa and prostatic fluid in dogs with benign prostatic hyperplasia (BPH) by the determination of total antioxidant capacity and protein peroxidation markers. Study was conducted on 40 intact dogs of various breeds. The dogs were assigned to two groups: BPH group (n=20) and non-affected group (n=20). The second and third fractions of the ejaculate were collected separately by digital manipulation. Total antioxidant capacity (TAC) and the concentrations of SH-groups in sperm and prostatic fluid were determined spectrophotometrically, the concentrations of bityrosine and formylkynurenine were determined using spectrofluorimetric methods. The mean values of TAC in spermatozoa and prostatic fluid were significantly lower (p<0.05), whereas the mean contents of biotyrosine and formylkinurenine were significantly higher (p<0.05) in BPH dogs compared to control dogs. There was no statistically significant difference in the content of SH group between dogs with BPH and control dogs (p>0.05). In conclusion, the results indicate that BPH in dogs is associated with reduced total antioxidant capacity and increased protein oxidation in the prostatic fluid and spermatozoa, and suggest the importance of oxidative stress in the pathogenesis of this condition. The potential role of antioxidants in the prevention and therapy of canine BPH requires further studies.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38088310/