Peer-reviewed veterinary case report
Cathepsin K inhibitor helps delayed tooth replantation in dogs
By Kwon, Youngil et al.·Published in Dental traumatology : official publication of International Association for Dental Traumatology·2018·Department of Conservative Dentistry, South Korea·View original on PubMed →
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Original publication title: The effect of cathepsin K inhibitor surface treatment on delayed tooth replantation in dogs.
- Species:
- dog
Plain-English summary
A group of four Beagle dogs had their premolar teeth extracted and then replanted after a delay to see if a special treatment could help with healing. The teeth were either treated with a cathepsin K inhibitor or left untreated before being put back in their sockets. After 12 weeks, the researchers found no significant difference in inflammation or healing between the two groups. This means that the cathepsin K inhibitor did not help reduce root resorption (the loss of tooth structure) after the teeth were replanted.
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Abstract
BACKGROUND/AIM: Continuous research efforts have been focusing on promoting healing of delayed replantation of avulsed teeth. The aim of this in vivo study was to assess the effect of cathepsin K inhibitor surface treatment on delayed tooth replantation. MATERIALS AND METHODS: Thirty-four premolar roots of 4 beagle dogs were extracted, and conventional root canal treatment was performed. The canals were filled with gutta-percha and cement. All extracted teeth were air-dried for 1 hour. Teeth were divided into 2 groups according to the root surface treatment prior to replantation: control (n = 13) and cathepsin K inhibitor (n = 21). Treated teeth were replanted in their original sockets and stabilized with a resin-wire splint for 1 week. After 12 weeks, the dogs were euthanized and micro-computed tomography was performed. Tissues were then further processed as resin-embedded specimens stained with hematoxylin and eosin. In each evaluation, data were analyzed using the Mann-Whitney U test (P < .05). RESULTS: In the micro-computed tomography evaluation, inflammation scores of both groups were not statistically different (P > .05). In the histological evaluation, the mean proportions of inflammatory resorption and replacement resorption in the control group were similar to those in the cathepsin K inhibitor group (P > .05). CONCLUSIONS: Cathepsin K inhibitor did not demonstrate significant inhibitory effects on root resorption after delayed replantation in vivo.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29533502/