Peer-reviewed veterinary case report
Does giving carprofen with omeprazole increase gut problems in dogs
By Jones, Susan M et al.·Published in Journal of veterinary internal medicine·2020·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs.
- Species:
- dog
Plain-English summary
A group of healthy adult beagle dogs was tested to see how the combination of carprofen (a common pain medication) and omeprazole (a stomach acid reducer) affected their digestive health. The study found that giving both medications together increased markers of gut inflammation and dysbiosis (an imbalance in gut bacteria) compared to giving carprofen alone or no treatment at all. This suggests that while omeprazole is often used to protect the stomach when giving pain medications, it may actually worsen gut health in healthy dogs.
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Abstract
BACKGROUND: Proton pump inhibitors (eg, omeprazole) commonly are administered concurrently with nonsteroidal anti-inflammatory drugs (NSAIDs; eg, carprofen) as prophylaxis to decrease the risk of gastrointestinal (GI) injury. However, evidence to support this practice is weak, and it might exacerbate dysbiosis and inflammation. HYPOTHESIS/OBJECTIVES: To evaluate the effect of carprofen alone or combined with omeprazole in dogs. We hypothesized that coadministration of omeprazole and carprofen would significantly increase GI permeability and dysbiosis index (DI) compared to no treatment or carprofen alone. ANIMALS: Six healthy adult colony beagle dogs. METHODS: Gastrointestinal permeability and inflammation were assessed by serum lipopolysaccharide (LPS) concentration, plasma iohexol concentration, fecal DI, and fecal calprotectin concentration in a prospective, 3-period design. In the first 7-day period, dogs received no intervention (baseline). During the 2nd period, dogs received 4 mg/kg of carprofen q24h PO for 7 days. In the 3rd period, dogs received 4 mg/kg of carprofen q24h and 1 mg/kg of omeprazole q12h PO for 7 days. Gastrointestinal permeability testing was performed at the end of each period. Data were analyzed using repeated measures mixed model analysis of variance with Tukey-Kramer post hoc tests (P < .05). RESULTS: Serum LPS and plasma iohexol concentrations did not differ between treatments. Fecal calprotectin concentrations differed between treatments (P = .03). The DI varied over time based on the treatment received (P = .03). Coadministration of omeprazole and carprofen significantly increased fecal calprotectin concentration and DI compared to baseline and carprofen alone. CONCLUSIONS AND CLINICAL IMPORTANCE: Omeprazole prophylaxis induces fecal dysbiosis and increases intestinal inflammatory markers when coadministered with carprofen to otherwise healthy dogs with no other risk factors for GI bleeding.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32893926/