Peer-reviewed veterinary case report
Does omeprazole affect clopidogrel blood levels and platelet function
By Plante, Christina et al.Ā·Published in Journal of veterinary internal medicineĀ·2024Ā·University of Montreal, CanadaĀ·View original on PubMed ā
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Original publication title: The effect of concurrent clopidogrel and omeprazole administration on clopidogrel metabolism and platelet function in healthy cats.
- Species:
- cat
Plain-English summary
Ten healthy cats were given either clopidogrel, a medication that helps prevent blood clots, or clopidogrel along with omeprazole, a drug that reduces stomach acid, to see how the combination affected their blood. After 10 days, the cats taking both medications had lower levels of the active form of clopidogrel in their blood, but their ability to form blood clots didn't change significantly compared to those taking clopidogrel alone. This suggests that while the combination affects how the body processes clopidogrel, it doesn't seem to impact its effectiveness in preventing blood clots in the short term.
People also search for: cat clopidogrel omeprazole interaction Ā· cat blood clot prevention medication Ā· effects of omeprazole on cat medication
Abstract
BACKGROUND: Some studies in humans show that the concurrent use of clopidogrel and omeprazole decreases plasma clopidogrel active metabolite (CAM) concentrations and clopidogrel antiplatelet effects. Whether this drug interaction occurs in cats is unknown. HYPOTHESIS: We hypothesized that administration of clopidogrel with omeprazole would decrease plasma CAM concentrations and decrease clopidogrel antiplatelet effects in healthy cats. ANIMALS: Ten domestic cats. METHODS: In this 2-sequence, 2-period, 2-treatment randomized crossover study, healthy cats were randomly assigned to receive clopidogrel only (18.75 mg PO q24h) or clopidogrel with omeprazole (1 mg/kg PO q12h) for 10 days, followed by a 2-week washout period, and then the opposite treatment for another 10 days. Blood was collected by jugular venipuncture on days 0, 5, and 10. Plasma CAM concentrations were measured using high-performance liquid chromatography-tandem mass spectrometry. Platelet function was evaluated using Plateletworks, Multiplate Analyzer, and Platelet Function Analyzer-100 (PFA-100). RESULTS: Multiplate Analyzer and PFA-100 detected no difference in platelet function between days or treatment groups. Plateletworks detected a significant difference (P < .001) in platelet function from day 0 to 5 and day 0 to 10 in both treatment groups but no difference between treatment groups. Plasma CAM concentrations were significantly lower on day 10 (P < .02) in cats receiving both medications versus clopidogrel only. CONCLUSIONS AND CLINICAL IMPORTANCE: Concurrent omeprazole and clopidogrel administration was associated with altered pharmacokinetics on day 10, but no difference in pharmacodynamics between the 2 treatment groups. The short-term use of clopidogrel and omeprazole does not seem to alter platelet function significantly.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39439219/