Peer-reviewed veterinary case report
The effect of Cox-2 specific inhibition on direct fracture healing in the rabbit tibia.
- Journal:
- Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
- Year:
- 2011
- Authors:
- Hak, David J et al.
- Affiliation:
- Denver Health/University of Colorado · United States
- Species:
- rabbit
Abstract
OBJECTIVE: The purpose of this study was to evaluate the effect of Cox-2 administration on direct (primary) fracture healing. METHODS: A transverse tibial osteotomy was created in adult male rabbits and rigidly fixed in compression using a 2.7-mm dynamic compression plate. Animals were randomized to receive either rofecoxib (12.5 mg orally per day) or placebo. Animals were killed at 4 weeks and fracture healing assessed by mechanical testing. RESULTS: There were no significant differences between the control and Cox-2 treated animals in terms of mechanical strength at 4 weeks. There was a high complication rate of peri-implant fractures during the daily medication administration. CONCLUSION: The immediate administration of a Cox-2 specific inhibitor did not impair primary (direct) bone healing at the dose administered in this rabbit tibial osteotomy model.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21264481/