Peer-reviewed veterinary case report
Doxycycline improves hip osteoarthritis symptoms in dogs over 6 months
By Nganvongpanit, Korakot et al.·Published in Journal of veterinary science·2009·Department of Veterinary Biosciences and Public Health·View original on PubMed →
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Original publication title: The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial.
- Species:
- dog
Plain-English summary
Twenty-five dogs with hip osteoarthritis were given either doxycycline or chondroitin sulfate to see which treatment worked better. The dogs receiving doxycycline showed significant improvements in limping, joint movement, and overall comfort over six months. Their pain levels decreased, and their ability to bear weight improved. The study found that doxycycline was effective in helping dogs with hip arthritis feel better and move more easily.
People also search for: dog hip osteoarthritis treatment · doxycycline for dog arthritis · dog limping improvement · chondroitin sulfate for dogs
Abstract
Twenty-five dogs were included in a randomized, double-blind trial to assess the efficacy of doxycycline (DOX) orally administered twice a day at 4 mg/kg/day (n = 12) for the treatment of osteoarthritis of the hip. Chondroitin sulfate (CS; 525 mg/day) was used as a positive control (n = 13). Dogs were re-examined monthly for 6 months after initiation of treatment. The assessment protocol included clinical score, radiographic findings and serum osteoarthritis biomarkers. Dogs treated with DOX showed statistically significant improvements (p < 0.05) in lameness, joint mobility, pain on palpation, weight-bearing and overall score at 2, 6, 4, 4 and 4 months, respectively, after treatment. Biomarker levels of CS-WF6 epitope and hyaluronan were significantly increased and decreased (p < 0.05) at 2 and 3 months after treatment compared to pretreatment. These results showed that DOX had a positive therapeutic effect in dogs with osteoarthritis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19687625/