Peer-reviewed veterinary case report
How hip dysplasia affects blood and stress markers in dogs
By Polat, E et al.·Published in Polish journal of veterinary sciences·2021·rat University·View original on PubMed →
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Original publication title: The effect of hip dysplasia on some biochemical parameters, oxidative stress factors and hematocrit levels in dogs.
- Species:
- dog
Plain-English summary
A group of 27 dogs, including 16 with hip dysplasia and 11 with healthy hips, were studied to see how hip dysplasia affects their health. The dogs with hip dysplasia had higher levels of certain enzymes (alkaline phosphatase and creatine kinase) and showed signs of oxidative stress, which can indicate cell damage. However, their calcium and phosphorus levels were similar to those of healthy dogs. Understanding these differences can help veterinarians manage the health of dogs with hip dysplasia better.
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Abstract
In this study, it was aimed to investigate the effect of hip dysplasia on some biochemical parameters, oxidative stress factors and hematocrit values in dogs. Hematocrit values (HTC), serum calcium (Ca), phosphorus (P) levels, serum alkaline phosphatase (ALP), creatine kinase (CK) activities and oxidative stress factors were evaluated in a total of 27 dogs with healthy hip joints (n: 11) and hip dysplasia (n: 16). There was no statistically significant difference between the two groups in terms of HCT, Ca and P values (p˃0.05). ALP and CK activities were found to be statistically significantly increased in the group with hip dysplasia compared to the control group with a healthy hip joint (p˂0.05). While malondialdehyde (MDA) level, one of the oxidative stress factors, was increased in the group with hip dysplasia, decreased glutathione (GSH) levels, catalase (CAT) and glutathione peroxidase (GSH-Px) activities were significantly decreased. There was no significant difference between the two groups in terms of superoxide dismutase (SOD) level. As a result, it was determined that oxidative stress factors differ in dogs with hip dysplasia compared to dogs with the healthy hip joint.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35179835/