Peer-reviewed veterinary case report
Bleomycin injections to treat dog mouth tumors and results
By Yoshida, K et al.·Published in Journal of the American Animal Hospital Association·1998·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: The effect of intralesional bleomycin on canine acanthomatous epulis.
- Species:
- dog
Plain-English summary
Four dogs with a type of gum tumor called acanthomatous epulis were treated with a medication called bleomycin, injected directly into the tumors once a week. In three of the dogs, the tumors were no longer noticeable within three to eight weeks, and the fourth dog saw its tumor disappear after ten injections. Throughout the treatment, none of the dogs experienced any side effects. This suggests that bleomycin may effectively shrink these tumors without causing harm to the dogs.
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Abstract
Four dogs with recurrent acanthomatous epulis (AE) were injected with bleomycin (5 mg) intralesionally once a week. In three cases, tumors were clinically indistinguishable within three-to-eight weeks. In the fourth case, the tumor disappeared after 10 weekly injections. Through the administration period of bleomycin, no adverse reactions were recognized in any case. Electron microscopic examination together with a decrease in the percentage of mitotic cells implied that bleomycin might inhibit deoxyribonucleic acid (DNA) synthesis of tumor cells.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9826279/