Peer-reviewed veterinary case report
The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats.
- Journal:
- Journal of neuroscience methods
- Year:
- 2011
- Authors:
- Kovács, Zsolt et al.
- Affiliation:
- Department of Zoology
- Species:
- rodent
Abstract
Dimethyl sulfoxide (DMSO) is a widely used solvent for water-insoluble molecules and it has antioxidant, neuroprotective and cryopreservative effects. While DMSO is a regularly used solvent in research and a therapeutic agent, several cases of DMSO evoked seizures were reported in the literature. Therefore, we investigated the effect of different doses of DMSO on the absence-like epileptic activity of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21320528/