Peer-reviewed veterinary case report
How low dose rocuronium affects eye and breathing in dogs
By Auer, Ulrike et al.·Published in Veterinary ophthalmology·2007·Clinic of Anesthesiology and Perioperative Intensive Care·View original on PubMed →
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Original publication title: The effect of low dose rocuronium on globe position, muscle relaxation and ventilation in dogs: a clinical study.
- Species:
- dog
Plain-English summary
Sixteen dogs of various breeds were given a low dose of rocuronium, a muscle relaxant, during anesthesia for an eye exam. The treatment helped position their eyes centrally without significantly affecting their breathing. After receiving the medication, the dogs' eye position improved within seconds and stayed that way for about 23 minutes. Importantly, their ability to breathe remained stable throughout the procedure. This suggests that rocuronium can be safely used in dogs for short procedures requiring muscle relaxation without compromising their ventilation.
People also search for: dog eye position treatment · rocuronium effects in dogs · anesthesia for dog eye exam
Abstract
OBJECTIVE: The purpose of this study was to evaluate globe position, muscle relaxation and changes in ventilatory parameters after intravenous administration of 0.1 mg/kg rocuronium. STUDY DESIGN: Prospective clinical study. ANIMAL STUDIED: Sixteen dogs of different breeds, with a body weight of 22.1 +/- 13 kg and age of 5.6 +/- 2.8 years (mean +/- SD), were anesthetized for a short ophthalmic examination requiring central position of the globe. PROCEDURES: All dogs were premedicated with 0.005 mg/kg medetomidine and 0.1 mg/kg methadone IV. Anesthesia was induced with propofol to effect and maintained with 10 mg/kg/h propofol by continuous rate infusion. Following endotracheal intubation all dogs breathed 100% oxygen via an anesthetic circle system. Neuromuscular function was assessed with an acceleromyograph (TOF-Guard, Organon Teknika NV, Turnhout, Belgium) and by stimulation of the nervus peroneus superficialis. The ventilation parameters were measured using spirometry and capnography. After baseline measurements 0.1 mg/kg rocuronium was administered IV. Minute volume (MV), tidal volume (Vt), respiratory rate (RR), end expiratory carbon dioxide concentration (PE'CO(2)) and maximal depression of the response of the first twitch (T1) of train-of-four (TOF) stimulation and train-of-four ratio (TOFR) was measured. The change in the position of the globe was recorded. RESULTS: T1 decreased to 61 +/- 18% and the TOF ratio to 45 +/- 21% of baseline values. Both parameters returned to baseline after 9 min. There was no significant reduction in MV, TV and RR and no increase in PE'CO(2). The globe rotated to a central position of 45 +/- 7.7 s after administration of rocuronium and remained there for 23 +/- 10.8 min in all dogs. CONCLUSION: Rocuronium administered intravenously at a dose of 0.1 mg/kg to dogs causes a central position of the globe but minimal impairment of ventilation parameters.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17760708/