Peer-reviewed veterinary case report
The effect of pentoxifylline on existing hypersensitivity in a rat model of neuropathy.
- Journal:
- Anesthesia and analgesia
- Year:
- 2008
- Authors:
- Liu, Jian et al.
- Affiliation:
- Department of Anaesthesiology · China
- Species:
- rodent
Abstract
BACKGROUND: Using a rat L5 spinal nerve transection model we previously showed that pentoxifylline prevents hyperalgesia through antiinflammation in the prefrontal brain. In this study, we examined efficacy when applied after injury. METHODS: We examined the effect of pentoxifylline on existing mechanical allodynia, observing glial activation and proinflammatory cytokine expression in the lumbar spinal cord, when given 7 days after L5 spinal nerve transection. RESULTS: There was no effect from pentoxifylline on existing hypersensitivity, glial activation, and cytokine expression when applied after L5 spinal nerve transection. CONCLUSION: Pentoxifylline administered intraperitoneally on day 7 postsurgery failed to alleviate existing hypersensitivity, or reduce glial activation and cytokine expression.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18227329/