Peer-reviewed veterinary case report
How prednisone changes the look of dog mast cell tumors
By Linde, Ken J et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2021·University of Pennsylvania School of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: The effect of prednisone on histologic and gross characteristics in canine mast cell tumors.
- Species:
- dog
Plain-English summary
A group of 28 dogs with large mast cell tumors (MCT) were treated with prednisone, a common steroid, before surgery to see if it would help shrink the tumors. The dogs received prednisone for about a week to two weeks before their tumors were surgically removed. While the treatment did not change the tumor's characteristics under the microscope, it significantly reduced the size of the tumors, making them easier to remove. This suggests that using prednisone before surgery can be a helpful option for dogs with these types of tumors.
People also search for: dog mast cell tumor treatment · prednisone for dog tumors · how to shrink dog tumors before surgery
Abstract
The objective of the study was to determine whether neoadjuvant prednisone therapy affects histological features of cutaneous and subcutaneous mast cell tumors. Twenty-eight dogs with a treatment naïve > 1-cm diameter mast cell tumor (MCT) were randomly assigned (Random number generator; Random.org, Dublin, Ireland) in a blinded fashion to receive either prednisone or placebo (Quality Food Center Pharmacy, Kirkland, Washington, USA). Volumes of mast cell tumors were calculated before incisional and excisional biopsies. Following incisional biopsy, patients received either prednisone (1 mg/kg body weight) daily or a placebo for 7 to 14 days leading up to excisional biopsy. Tumor grade for cutaneous MCT, and mitotic count and atypia for all tumors were reported. Perioperative treatment with prednisone had no significant effect on tumor grade, atypia, or mitotic count. Tumor volume was significantly decreased with prednisone treatment. The use of neoadjuvant prednisone to decrease MCT volume in order to facilitate tumor excision, can be considered without significant concern for change of tumor histologic features in the common population of low- to intermediate-grade MCT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33390598/