Peer-reviewed veterinary case report
Do eye drops delay glaucoma in dogs with closed-angle glaucoma
By Stavinohova, R et al.·Published in The Journal of small animal practice·2015·Comparative Ophthalmology Unit·View original on PubMed →
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Original publication title: The effect of prophylactic topical carbonic anhydrase inhibitors in canine primary closed-angle glaucoma.
- Species:
- dog
Plain-English summary
A group of 40 dogs with primary closed-angle glaucoma (a type of eye condition) were treated with different medications to see if they could prevent glaucoma from developing in the other eye. The treatments included brinzolamide, dorzolamide, and a combination of dorzolamide with timolol. Unfortunately, the study found that none of these treatments significantly delayed the rise in eye pressure in the second eye, and many dogs still developed glaucoma over time. Overall, the medications did not prove effective in preventing this serious eye condition from affecting the other eye.
People also search for: dog glaucoma treatment · eye pressure medication for dogs · preventing glaucoma in dogs
Abstract
OBJECTIVES: To determine the effect of 1% brinzolamide, 2% dorzolamide hydrochloride or combination 2% dorzolamide hydrochloride/0 · 5% timolol to delay the elevation of the intraocular pressure in second eyes of dogs with primary closed-angle glaucoma. METHODS: Analysis of retrospectively collated data from 40 dogs with primary closed-angle glaucoma, where the non-affected eye was treated prophylactically with brinzolamide (n = 10), dorzolamide (n = 18) or combination dorzolamide/timolol therapy (n = 12). RESULTS: The 40 treated dogs (median age of 76 · 2 months) comprised 25 females/15 males, 19 entire/21 neutered. Twenty dogs developed glaucoma in the contralateral eye (median time of 9 · 2 months). No statistically significant difference was identified during treatment failure between the treatment groups (P = 0 · 66). The second eye remained normotensive in 20 dogs; four dogs until the conclusion of the study (median: 27 · 0 months), three dogs until death (median: 15 · 4 months), seven dogs until lost to follow-up (median: 11 · 6 months). Out of these 20 dogs, treatment was discontinued because of lack of owner compliance in two dogs and following a local drug reaction in four dogs (median: 8 · 9 months). CLINICAL SIGNIFICANCE: There was no evidence that the tested drugs delayed elevation of intraocular pressure in contralateral eyes of dogs with primary closed-angle glaucoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26334202/