Peer-reviewed veterinary case report
Renaltec lowers harmful kidney toxins in cats with chronic kidney
By Paschall, Rene E. et al.·Published in Veterinary Sciences·2024·Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA, United States·View original on Crossref →
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Original publication title: The Effect of Renaltec on Serum Uremic Toxins in Cats with Experimentally Induced Chronic Kidney Disease
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) were given a treatment called Renaltec to see if it could help lower harmful toxins in their blood. Over a period of 56 days, the cats received either one or two doses of Renaltec daily, and the results showed that both dosing schedules significantly reduced the levels of these toxins. The cats that received two doses a day had better results compared to those that received just one dose. This suggests that Renaltec can be an effective option for managing toxin levels in cats with CKD.
People also search for: cat chronic kidney disease treatment · Renaltec for cats · how to lower uremic toxins in cats
Abstract
Serum uremic toxins markedly increase in cats with chronic kidney disease (CKD) and have deleterious consequences. Renaltec is an oral adsorbent that binds uremic toxin precursors in the gut. In this prospective cohort study utilizing 13 purpose-bred cats with remnant kidney model-induced CKD (12 IRIS Stage 2, 1 IRIS Stage 3) eating a standardized renal diet, we aimed to assess the effect of Renaltec administration on serum indoxyl sulfate (IDS) and p-cresol sulfate (pCS) concentrations. Cats were sequentially treated with standard of care for 56 days, 500 mg Renaltec orally once daily for 56 days, and then three months later, 500 mg Renaltec orally twice daily for 56 days. Serum IDS and pCS concentrations were measured 28 and 56 days after the administration of Renaltec. Blood pressure and kidney function were measured before and 56 days after the administration of Renaltec. Significant decreases in serum IDS and pCS concentrations were observed for both once- and twice-daily dosing, particularly during the first 28 days of administration. More cats with BID dosing had clinically significant reductions in serum IDS and pCS concentrations than with SID dosing. Renaltec can reduce the serum concentrations of deleterious gut-derived uremic toxins in cats with CKD.
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Search related cases →Original publication on Crossref: https://doi.org/10.3390/vetsci11080379