Peer-reviewed veterinary case report
How spaying surgery changes meloxicam levels in dogs after IV dose
By Karademir, Umit et al.·Published in BMC veterinary research·2016·Department of Pharmacology and Toxicology·View original on PubMed →
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Original publication title: The effect of surgery (Ovariohysterectomy) on the plasma disposition of meloxicam following intravenous administration in dogs.
- Species:
- dog
Plain-English summary
A group of eight female dogs undergoing spay surgery (ovariohysterectomy) were given a pain medication called meloxicam before and during the procedure to see how surgery affected the drug's effectiveness. The study found that the way meloxicam was distributed in the dogs' bodies changed after surgery, which could impact how well the medication works and increase the risk of side effects like stomach ulcers or kidney problems if given repeatedly. It's important for pet owners to discuss pain management options with their veterinarian, especially for dogs undergoing surgery.
People also search for: dog spay surgery pain management · meloxicam side effects in dogs · how long does meloxicam last in dogs
Abstract
BACKGROUND: Meloxicam (MLX) is a nonsteroidal anti-inflammatory drug used in the relief of postoperative pain for human and veterinary medicine. This study was designed to investigate the effect of surgery on the plasma disposition of MLX in dogs undergoing ovariohysterectomy following a single intravenous injection at a dose of 0.2 mg/kg bodyweight. Eight crossbred bitches were used in the study. A two-phase experimental design with a 10-day washout period was used. Pre-operative MLX was administered intravenously to 8 bitches about 10 days before surgery (Phase I, control) at a dose of 0.2 mg/kg bodyweight and peri-operative MLX was administered intravenously after anaesthesia and 15 min before the start of surgery (Phase II). Blood samples were collected from all animals at various times between 1 and 96 h after the drug administrations in both phases. The drug concentrations were analysed using high performance liquid chromatography. RESULTS: The volume of plasma MLX distribution at steady-state (Vdss) of the control group (Vdss: 263.0 ml/kg) was significantly greater (P < 0.05) compared to that of the surgery group (Vdss: 149.3 ml/kg). The AUC values were higher (29.5 vs. 23.0 μg.h(2)/ml) and the CL values were lower (7.7 vs. 10.5 ml.h/kg) in the surgery group compared to the control group, respectively, but differences were not significant. CONCLUSIONS: The results of the present study indicated that surgery could alter the plasma disposition of MLX and thus the drug efficacy and side effects such as gastrointestinal ulceration, unusual bleeding and loss of kidney function/failure when repeated doses are used.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26896943/