Peer-reviewed veterinary case report
Effectiveness of PCSO-524 and firocoxib for dog osteoarthritis pain
By Vijarnsorn, Monchanok et al.·Published in BMC veterinary research·2019·Department of Companion Animals Clinical Sciences. Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis.
- Species:
- dog
Plain-English summary
A group of dogs with hip and knee arthritis were treated with either a marine-based fatty acid supplement called PCSO-524, a common pain medication called firocoxib, or a combination of both for four weeks. All treatments helped improve the dogs' ability to bear weight and reduced pain, but the combination of PCSO-524 and firocoxib showed the best results. While some dogs had slight increases in kidney values, they remained within normal limits. Overall, using both treatments together appeared to provide better relief from arthritis symptoms than using either one alone.
People also search for: dog arthritis treatment · PCSO-524 for dogs · firocoxib side effects in dogs
Abstract
BACKGROUND: NSAIDs are accepted as the most predictably efficacious medical treatment of the clinical signs of osteoarthritis (OA). The marine-based fatty-acid compound PCSO-524 has been proposed as an adjunctive treatment for canine OA, however benefits of this agent is still controversial. The purpose of this study was to evaluate and compare the effectiveness of PCSO-524 combined with the NSAID firocoxib using force plate gait analysis, orthopedic assessment score (OAS) and canine brief pain inventory score (CBPI) in dogs with OA. A prospective, randomized, double-blinded study was conducted. Seventy-nine dogs that had hip and/or stifle OA were assigned randomly into three treatment groups: firocoxib, PCSO-524 and combination of firocoxib and PCSO-524, orally for 4 weeks. Peak vertical force (PVF, expressed as a percentage of bodyweight), OAS, CBPI, serum prostaglandin Econcentration, hematology and blood chemistry values were evaluated before treatment (Day0), as well as at the second (Day14) and fourth week (Day28) during treatment. RESULTS: Within group analysis revealed significant increases in PVF over the 4-week treatment period for firocoxib, PCSO-524 and the combination (p < 0.05). Mean increases in PVF were 3.25 ± 4.13, 2.01 ± 3.86, 4.11 ± 4.69%BW (mean ± SD) respectively. The OAS showed non-significant change in all treatment groups. There were significant decreases in CBPI pain severity score (PSS) and CBPI pain interference scores (PIS) within some groups over time, however no significant differences were found between the groups. Significantly decreased serum PGEconcentration (p < 0.05) was found in the combination group. Significant increases in BUN and creatinine (p < 0.05) compared to pre-treatment values were found in the firocoxib and combination groups but not in the PCSO-524 group at day28, but all values in all dogs remained within the normal ranges. CONCLUSIONS: The results of this study suggested combination of both PCSO-524 and firocoxib is more effective in alleviation of inflammation and improvement of weight bearing ability when compared to the uses of either PCSO-524 or firocoxib alone. Further clinical studies are needed to confirm this, and to determine if there is any benefit of PCSO-524 over placebo.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31623621/