Peer-reviewed veterinary case report
5-HT2A blocker improves blood flow in dog lumbar disc herniation model
By Sekiguchi, Miho et al.·Published in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2008·Department of Orthopaedic Surgery, Japan·View original on PubMed →
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Original publication title: The effects of a 5-HT2A receptor antagonist on blood flow in lumbar disc herniation: application of nucleus pulposus in a canine model.
- Species:
- dog
Plain-English summary
A group of 13 dogs with lumbar disc herniation had surgery to apply a substance called nucleus pulposus to their nerve roots, which can cause pain and reduced blood flow. Researchers tested a medication called a 5-HT2A receptor antagonist to see if it could improve blood flow in these affected areas. After treatment, the dogs showed a significant increase in blood vessel diameter and blood flow compared to those who did not have surgery. This suggests that the medication could help improve blood flow in dogs suffering from lumbar disc herniation, potentially easing their pain and discomfort.
People also search for: dog lumbar disc herniation treatment · improving blood flow in dogs · 5-HT2A receptor antagonist for dogs
Abstract
Blood vessel clots are found around the nerve root in patients with lumbar disc herniation. Thrombosis formation in the experimental application of nucleus pulposus to the nerve root has been shown in histological studies. In addition, reduction of blood flow and nerve conduction velocity are induced by the application of nucleus pulposus, which mimics lumbar disc herniation. In patients with lumbar disc herniation, nerve root block, which is thought to increase nerve blood flow, improves radiculopathy. 5-HT(2A) receptor antagonists are used in chronic arterial occlusive diseases to improve blood flow and have been reported to work as well as nonsteroidal anti-inflammatory drugs in improving radiculopathy due to lumbar disc herniation in clinical studies. This study investigated the effects of a 5-HT(2A) receptor antagonist on blood vessel diameter and blood flow in a canine experimental model of lumbar disc herniation. A total of 13 dogs were used. The animals were divided into three experimental groups and surgery was performed 1 week before measurements. In the nucleus pulposus group (NP; n = 5), the nucleus pulposus was applied to the nerve roots from the ventral side. In the sham group (n = 5), nucleus pulposus was not applied. In the naive group (n = 3), the animals did not undergo surgery. Measurements of vessel diameter and blood flow were done before and after administration of saline and drugs. The diameters and blood flow volume of the observed blood vessels were measured on video-recordings every 10 min for 65 min. In all groups, vessel diameter and blood flow did not change before or after administration of saline. In the NP and sham groups, vessel diameter and blood flow increased significantly after administration of 5-HTRA compared with the naive group. 5-HTRA improved blood vessel diameter and blood flow in the nerve roots inflamed by the application of nucleus pulposus but not in the intact nerve roots. 5-HTRA might be a potential agent to improve blood flow in the nerve roots of patients with lumbar disc herniation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17973126/