Peer-reviewed veterinary case report
How cyclosporine affects blood clotting in healthy dogs
By Thomason, J et al.·Published in Journal of veterinary internal medicine·2012·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: The effects of cyclosporine on platelet function and cyclooxygenase expression in normal dogs.
- Species:
- dog
Plain-English summary
Eight healthy female dogs were given cyclosporine, a medication often used to suppress the immune system, to see how it affected their blood platelets. The higher dose led to a significant decrease in platelet activity, which could increase the risk of blood clots. In contrast, a lower dose used for treating skin allergies showed less impact on platelet function. This suggests that while cyclosporine can be effective for certain conditions, it may also pose risks for blood clotting, especially at higher doses. If your dog is on cyclosporine, it's important to discuss any potential risks with your veterinarian.
People also search for: dog cyclosporine side effects · dog blood clot risk · dog immune system medication effects
Abstract
BACKGROUND: Cyclosporine has been shown to alter platelet plasma membranes and have a hypercoagulable effect in humans, leading to thromboembolic complications. HYPOTHESIS/OBJECTIVES: Our hypothesis was that by modulating platelet reactivity, cyclosporine increases the risk of thromboembolic complications. The objective was to determine the effects of cyclosporine on primary hemostasis in normal dogs. ANIMALS: Eight healthy, intact female dogs. METHODS: A repeated-measures design utilized flow cytometry to evaluate platelet expression of platelet reactivity markers (P-selectin and phosphatidylserine) and COX-1 and COX-2 during the administration of 2 cyclosporine dosages (19 mg/kg q12h [immunosuppressive dosage] and 5 mg/kg q24h [atopy dosage]). Urine 11-dehydro-thromboxane-B(2) (11-dTXB(2) ) concentration was normalized to urine creatinine concentration, and platelet function was analyzed by PFA-100. RESULTS: After a week of the immunosuppressive dosage, all platelet reactivity markers showed a significant decrease in mean fluorescent intensity (MFI). After the atopy dosage, only P-selectin and COX-2 MFI demonstrated a change from baseline, decreasing by 29% (P = .013) and 31% (P = .003), respectively. Urinary 11-dTXB(2) -to-creatinine ratio significantly increased at all time points during the immunosuppressive dosage, but no significant change occurred during administration of the atopy dosage. PFA-100 closure times using collagen/ADP cartridges increased by 62% (P = .008) with the immunosuppressive dosage and decreased by 45% with the atopy dosage (P = .035). No significant changes in closure times occurred with collagen/epinephrine cartridges. CONCLUSIONS AND CLINICAL IMPORTANCE: Our study suggests that, similar to what is observed in humans, cyclosporine alters the platelet plasma membrane and increases thromboxane production in dogs, especially at immunosuppressive dosages.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23106529/