The effects of increased ischemic times on adipose tissue: a histopathologic study using the epigastric flap model in rats.

Abstract

Little study has investigated the ischemic injury of mature adipocytes. This study researched the effects of different ischemic times on fat histology the 7th postischemic day in a rat epigastric flap model. For this study, 24 rats were randomly divided into four groups subjected, respectively, to 1, 2, 3, and 4 h of ischemia. The most severe inflammation and fat necrosis scores were seen in groups 3 and 4 (p < 0.05). According to the findings of this study, it is possible to say that fat tissue undergoes a gross necrosis after 3 or more hours of ischemia. After that ischemic time, the necrotic volume of fat tissue subjected to ischemic insult does not increase with increased ischemic time.