Peer-reviewed veterinary case report
Ketamine-midazolam anesthesia effects on eye pressure in normal dogs
By Ghaffari, Masoud Selk et al.·Published in Veterinary ophthalmology·2010·Department of Clinical Sciences·View original on PubMed →
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Original publication title: The effects of ketamine-midazolam anesthesia on intraocular pressure in clinically normal dogs.
- Species:
- dog
Plain-English summary
A group of 13 healthy mixed-breed dogs was given a combination of ketamine and midazolam for anesthesia to see how it affected their eye pressure. The researchers measured the dogs' intraocular pressure (IOP) before and after the treatment and found that the anesthesia did not significantly change the eye pressure compared to a control group that received saline. This means that using this anesthesia combination is safe for dogs in terms of eye pressure.
People also search for: dog eye pressure anesthesia · ketamine midazolam effects on dogs · safe anesthesia for dogs
Abstract
OBJECTIVE: To determine the effects of intravenous ketamine-midazolam anesthesia on intraocular pressure (IOP) in ocular normotensive dogs. ANIMALS: Thirteen adult mixed-breed dogs. PROCEDURES: Dogs were randomly assigned to treatment (n = 7) and control (n = 6) groups. Dogs in the treatment group received intravenous ketamine 15 mg/kg and midazolam 0.2 mg/kg and dogs in the control group received intravenous saline. The time of intravenous drug injection was recorded (T(0)). Measurements of IOP were then repeated 5 min (T(5)) and 20 min (T(20)) following the intravenous administration of ketamine-midazolam combination and saline in both groups. RESULTS: Measurements showed normal IOP values in both groups. The mean + or - SD baseline IOP values for treatment and control groups were 13.00 + or - 1.47 and 10.33 + or - 2.20, respectively. For baseline IOP values, there was no significant difference between treatment and control groups (P = 0.162). In the treatment group, the subsequent post-treatment mean + or - SD values were 15.64 + or - 2.17 (5 min), and 14.92 + or - 1.98 (20 min). There was no evidence of statistical difference between baseline values and post-treatment values after treatment with ketamine-midazolam (P(5) = 0.139; P(20) = 0.442). In control eyes, the mean + or - SD values at 5 and 20 min were 10.41 + or - 2.01 and 10.16 + or - 1.69, respectively. There was no significant difference between baseline values and post-treatment values in control group (P(5) = 1.000; P(20) = 1.000). CONCLUSION: Ketamine-midazolam combination has no clinically significant effect on IOP in the dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20447026/