Peer-reviewed veterinary case report
The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy.
- Journal:
- Brain research. Developmental brain research
- Year:
- 2005
- Authors:
- Ateş, Nurbay et al.
- Affiliation:
- Department of Physiology
- Species:
- rodent
Abstract
This study was designed to investigate whether the intensity of experimental febrile seizures reduces the threshold to generalized tonic-clonic epilepsy and its effects on the development of generalized absence epilepsy in adulthood. For the evaluation of absence epilepsy, WAG/Rij rats and for the tonic-clonic seizures, PTZ injected Wistar rats were used. Our results showed that while the frequency of the experimental febrile seizures facilitates PTZ-induced generalized tonic-clonic seizures, it does not influence the properties of absence epileptic seizures in adulthood.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15617762/