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Peer-reviewed veterinary case report

The Effects of Threefold 30-Minute Inhalation Sessions of an Argon-Oxygen Mixture on a Photochemically Induced Ischemic Stroke Model in Rats.

Journal:
Bulletin of experimental biology and medicine
Year:
2025
Authors:
Sutormin, M V et al.
Affiliation:
Moscow Regional Research and Clinical Institute ("MONIKI")
Species:
rodent

Abstract

Studies on rats have demonstrated that successive threefold 30-min sessions of inhalation of an argon-oxygen mixture (Ar 70%/O30%) immediately after and on days 2 and 3 after ischemic stroke reduce neurological deficit, the area of vWFstaining in brain sections, and the number of Iba-1and Cas-3cells in the lesion focus and NeuNcells in the penumbra. However, no differences in the lesion volume were detected by MRI. Argon-oxygen inhalations reduced neurological deficits through their influence on reparative processes within the lesion site.

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Original publication: https://pubmed.ncbi.nlm.nih.gov/40682649/