Peer-reviewed veterinary case report
Topical eye drops delay glaucoma in dogs with one affected eye
By Miller, P E et al.·Published in Journal of the American Animal Hospital Association·2000·Department of Surgical Sciences, United States·View original on PubMed →
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Original publication title: The efficacy of topical prophylactic antiglaucoma therapy in primary closed angle glaucoma in dogs: a multicenter clinical trial.
- Species:
- dog
Plain-English summary
A group of dogs with one eye affected by primary closed angle glaucoma (PCAG) were treated to see if they could prevent the same problem in the other eye. Dogs received either a drop of betaxolol twice a day or a combination of demecarium bromide and a corticosteroid once a day. The untreated dogs developed glaucoma much sooner, while those treated with either option had a significant delay in developing the condition. The combination treatment was found to be just as effective but required less frequent dosing, making it a potentially better choice for preventing glaucoma in dogs.
People also search for: dog glaucoma treatment · betaxolol for dogs · demecarium bromide eye drops for dogs
Abstract
The ability of either 0.5% betaxolol (1 drop topically, bid; n=31) or a combination of 0.25% demecarium bromide and a topical corticosteroid (gentamicin/betamethasone) (DB/GB; 1 drop of each topically, sid; n=55) to prevent glaucoma in the fellow eye of dogs with unilateral, primary closed angle glaucoma (PCAG) was investigated in a multicenter, open-label, clinical trial. Untreated control dogs (n=20) developed glaucoma significantly sooner (median, eight mos; p less than 0.001) than dogs treated either with DB/GB (median, 31 mos) or betaxolol (median, 30.7 mos). Although DB/GB and betaxolol equally delayed or prevented the onset of glaucoma in the second eye, a less frequent dosing schedule for DB/GB suggests demecarium bromide in combination with a topical corticosteroid may be preferable to betaxolol in preventing PCAG in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/10997520/