Peer-reviewed veterinary case report
How cyclosporine and prednisone affect dog skin allergy scores
By Taszkun, I·Published in Polish journal of veterinary sciences·2010·Sub-department of Clinical Diagnostics and Veterinary Dermatology·View original on PubMed →
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Original publication title: The evaluation of Canine Atopic Dermatitis Extent and Severity Index (CADESI) test in dogs with atopic dermatitis (AD) treated with cyclosporine or prednisone.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy) were treated with either prednisone or cyclosporine to see which worked better. Both treatments were given for six weeks, and the dogs showed significant improvement in their skin condition, with a reduction in symptoms by about 82% for prednisone and 83% for cyclosporine. The results indicated that both medications were similarly effective in managing the dogs' skin issues. Pet owners can feel reassured that either treatment can help their dogs with atopic dermatitis.
People also search for: dog skin allergy treatment · prednisone for dog itching · cyclosporine for dog dermatitis
Abstract
The purpose of this study was to assess the clinical state of dogs with atopic dermatitis (AD) by use of CADESI test in own modification during the first visit in the Dermatology Consult Room as well as during the treatment. The study was performed in two groups (I-E and II-C) of 20 dogs in each group. In dogs which were qualified to the I-E group, as antiallergic, anti-inflammatory and antipruritic treatment, prednisone (oral preparation Encorton--Polfa Pabianice) at dose 0.5 mg/kg b.w./day was administered, while in dogs qualified to the II-C group--cyclosporine (oral preparation Sandimmun Neoral--Novartis Pharma) at a dose of 5 mg/kg b.w./day; the treatment was continued for 6 weeks in both groups. During the study, skin lesions were assessed in 15 specified body areas using 4 parameters and 5-point scale. In group I-E and II-C the amount of received points in CADESI test was decreased by 82.26% and by 83% respectively, after the treatment. Statistical analyses of the results obtained revealed no statistically significant (P = 0.05) differences between means of I-E and II-C groups in consecutive examinations, which indicates comparable clinical efficacy of both drugs. Statistically significant differences (P = 0.05) of the parameters assessed were found after secondary dermatoses treatment, and after every two weeks of antipruritic and anti-inflammatory treatment.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21370747/