Peer-reviewed veterinary case report
Fatal parvovirus infection in vaccinated dachshund
By Pelegrinová, Andrea et al.·Published in Veterinary research communications·2024·Department of Epizootiology·View original on PubMed →
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Original publication title: The first evidence of Asian-like CPV-2b in Slovakia in a vaccinated dog with an acute fatal course of parvovirus infection: a case report.
- Species:
- dog
Plain-English summary
A vaccinated dachshund puppy showed signs of severe illness, including vomiting, apathy, and bloody diarrhea, and was diagnosed with parvovirus infection. Despite receiving intensive treatment, the puppy sadly passed away within 48 hours of being admitted to the veterinary clinic. Testing revealed a new variant of the parvovirus that was linked to Asian strains, which had not been previously identified in Slovakia. This case highlights the emergence of a new parvovirus strain that can affect vaccinated dogs, underscoring the importance of monitoring for new infections.
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Abstract
This study provides a comprehensive description of the clinical course of a fatal parvovirus infection in a vaccinated dachshund puppy, along with the first identification of a new CPV-2 variant in Slovakia, elucidated through molecular amino acid analysis of the VP2 gene. The dog exhibited clinical signs such as apathy, vomiting, and bloody diarrhea. After confirming CPV-2 infection with a commercial snap test, intensive therapy was initiated. The dog succumbed within 48 h of admission. A rectal swab sample was collected, CPV-2 was examined using the PCR method, and sequenced. The virus detected in the patient was related to strains of CPV-2c of Asian origin and unrelated to European CPV-2b strains. The sequence had genetic signatures typical of Asian strains (VP2: 5Gly, 267Tyr, 324Ile, 370Arg, and 440Thr). Phylogenetic analysis classified this strain as similar to Asian strains of CPV-2c. It is believed to be derived from an Asian strain similar to CPV-2c that acquired the 426Asp mutation. With this finding, we present the first evidence of an Asian-like CPV-2b strain in the territory of Slovakia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39120673/