The first meta-analysis of the G96S single nucleotide polymorphism (SNP) of the prion protein gene () with chronic wasting disease in white-tailed deer.

Abstract

BACKGROUND: Prion diseases are irreversible infectious neurodegenerative diseases caused by a contagious form of prion protein (PrP). Since chronic wasting disease (CWD)-infected white-tailed deer are strong carriers of the prion seed through corpses via scavenger animals, preemptive control based on genetic information for a culling system is necessary. However, the risk of CWD-related genetic variants has not been fully evaluated. In the present study, we carried out a quantitative estimation of the risk of a G96S single nucleotide polymorphism (SNP) of thegene to CWD infection in white-tailed deer. METHODS: We carried out a literature search for genetic data of the G96S (c.286G>A) SNP of thegene from CWD-infected white-tailed deer and matched controls. We performed a meta-analysis using incorporated eligible studies to evaluate the association of the G96S SNP of thegene with susceptibility to CWD in white-tailed deer. RESULTS: We identified a strong association between the G96S (c.286G>A) SNP of thegene and susceptibility to CWD infection in white-tailed deer using meta-analysis. We observed the most significant association in the recessive model (odds ratio&#x202f;=&#x202f;3.0050, 95% confidence interval: 2.0593; 4.3851,&#x202f;<&#x202f;0.0001), followed by the additive model (odds ratio&#x202f;=&#x202f;2.7222, 95% confidence interval: 1.9028; 3.8945,&#x202f;<&#x202f;0.0001) and the heterozygote (AA vs. AG) comparison (odds ratio&#x202f;=&#x202f;2.7405, 95% confidence interval: 1.9215; 3.9085,&#x202f;<&#x202f;0.0001). CONCLUSION: To the best of our knowledge, this was the first meta-analysis of the association between the G96S (c.286G>A) SNP of thegene and susceptibility to CWD infection.