Peer-reviewed veterinary case report
The First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3.
- Journal:
- Viruses
- Year:
- 2021
- Authors:
- Lagan Tregaskis, Paula et al.
- Affiliation:
- Agri-Food and Biosciences Institute · United Kingdom
- Species:
- bird
Abstract
Avian nephritis virus (ANV) is classified in thefamily with disease associations with nephritis, uneven flock growth and runting stunting syndrome (RSS) in chicken and turkey flocks, and other avian species. The whole genome of ANV genotype 3 (ANV-3) of 6959 nucleotides including the untranslated 5' and 3' regions and polyadenylated tail was detected in a metagenomic virome investigation of RSS-affected chicken broiler flocks. This report characterises the ANV-3 genome, identifying partially overlapping open reading frames (ORFs), ORF1a and ORF1b, and an opposing secondary pseudoknot prior to a ribosomal frameshift stemloop structure, with a separate ORF2, whilst observing conserved astrovirus motifs. Phylogenetic analysis of thewhole genome and ORF2 capsid polyprotein classified the first complete whole genome of ANV-3 withingenogroup 2.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/33546203/